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Hongxing Liu
Associate Professor
Clinical focus
Molecular diagnosis of tumour and hereditary diseases, molecular identification, sorting of pathogenic microorganisms and molecular mechanism of individualised drug application.
Educational background
Master Degree, Biomedical Engineering, Peking University (2003-2006)
Bachelor Degree, Binzhou Medical University (1995-2000)
Work Experience
Director,Pathology and Medical Laboratory Department, Lu Daopei Hospital(2012-present)
Deputy Director, Laboratory Centre, Beijing Daopei Hospital (2011-2012)
Researcher, Molecular Diagnostic Laboratory, Beijing Daopei Hospital (2006-2011)
Consultant, Shandong Rizhao Donggang District Maternal and Child Health Hospital
Achievements
Invention Pattern: A gene detection kit for detecting cell chimerism or individual identification. Patent Number: CN200910178185.4
Professional Memberships
Committee Member of China Anti-Cancer Society Blood Tumour Special Committee Haematopathology Branch
Board Member of Beijing Immunology Society and Beijing Medical Laboratory Society
Standing Committee Member and Deputy Secretary General of Beijing Hematology and Osology Laboratory Branch of Beijing Medical Laboratory Society
Member of the Special Committee on Immunology Testing of Hebei Immunology Society
Editorial Board Member of SCIREA Journal of Clinical Medicine, Leukaemia-Lymphoma and Clinical and Pathology
Distinguished Experts of China Physicians Society Hematopoietic and Lymphoid Tumor Laboratory Medical Experts Committee
Member of ASCO (American Society of Clinical Oncology), ASH (American Society of Hematology), ASHG (American Society of Human Genetic Association)
Genetic Counsellor of GSC (Genetic Society of China)
Postoperative rhabdomyolysis after laparoscopic gastric bypass in morbidly obese patients 
Khurana, R. N., Baudendistel, T. E., Morgan, E. F., Rabkin, R. A., Elkin, R. B., & Aalami, O. O. (2004). Postoperative rhabdomyolysis after laparoscopic gastric bypass in the morbidly obese. ARCHIVES OF SURGERY, 139(1), 73-76.

Publications

A total of 39 academic papers and professional books have been published at domestic and international academic journals.

1. The application of HPLC-MS/MS method in the determination of whole blood concentration of Cyclosporine A and AM1 in bone marrow transplant patient

Wang Lei,Liu Hong Kongxing,Sun Wenli(2017).The application of HPLC-MS/MS method in the determination of whole blood concentration of Cyclosporine A and AM1 in bone marrow transplant patient .重庆医学,46(23):3234-7.

2. Application of HPLC-MS/MS Method in the Determination of Whole Blood Concentration of Tacrolimus in Bone Marrow Transplant Patient

Wang Lei,Liu Hong Kongxing,Sun Wenli(2017). Application of HPLC-MS/MS Method in the Determination of Whole Blood Concentration of Tacrolimus in Bone Marrow Transplant Patient. Journal of Modern Laboratory Medicine,2017,32(2):126-30.

3. Comparison and analysis of the blood concentration of cyclosporin A

Wang Lei,Sun Wenl,Li Peiyu,Tian Mengsu,Chen Xue;Zhang Yang,Liu Hongxing(2017).Comparison and analysis of the blood concentration of cyclosporin A. Chinese Journal of Clinicians(Electronic Edition),2017;11(3) :417-21.

4. Investigation report on cognition of clinical application of gene detection in hematological diseases

Jiang chunfei,Liu mei,Wei na, etc.(2016). Investigation report on cognition of clinical application of gene detection in hematological diseases. International Clinical Report,2016,3(2):1-6.

5. Relapsed/refractory childhood acute myeloid leukemia with congenital susceptible factors and complex gene mutation: report of one case and review of literature

Zhang Yang, Chen Xue, Wang Tong, Sun Ruijuan, Wang Hui, Wu Ping, Wang Fang, Liu Hongxing(2016). Relapsed/refractory childhood acute myeloid leukemia with congenital susceptible factors and complex gene mutation: report of one case and review of literature. Journal of Leukemia & Lymphoma,25(12):743-5.

6. Determination of Imatinib and Dasatinib in Leukemia Patients Plasma by HPLC-MS/MS

WANG Lei ,ZHOU Feng-ye ,JIANG Chun-fei ,TAO Bei-bei ,LIU Hong-xing(2016). Determination of Imatinib and Dasatinib in Leukemia Patients Plasma by HPLC-MS/MS. Journal of Modern Laboratory Medicine,31(1):128-31.

7. Mutation analysis of myeloproliferative neoplasms associated genes in patients first diagnosed as acute ischemic stroke

Tian Wenjun, Ren Xiaoxiao, Chen Xue, Liu Xiaohui, Zhang Yang, Teng Wen, Chert Yongjin, Sun Hui, Wang Fang, Zhang Zhifen, Wu Huanling, Li Yuantang, Zhang Bingchang, Liu Hongxing.(2015). Mutation analysis of myeloproliferative neoplasms associated genes in patients first diagnosed as acute ischemic stroke. Journal of Leukemia & Lymphoma,24(7):428-30, 436.

8. Mutaome profile of 10 common mutated genes in refractory and relapsed acute myeloid leukemia

Zhang Yang, Wang Fang, Chen Xue, Fang Jiancheng, Teng Wen, Wang Mangju, Wang Hui, Lin Yuehui, Pan Jing, Zhang Gailing, Wei Zhijie, Han Xiangping, Tong Chunrong, Liu Hongxing.(2015).Mutaome profile of 10 common mutated genes in refractory and relapsed acute myeloid leukemia. Journal of Leukemia & Lymphoma,24(5):261-4.

9. Mutaome analysis including 10 common mutated genes in newly diagnosed acute myeloid leukemia patients

Wang Fang, Zhang Yang, Chen Xue, Fang Jiancheng, Wang Mangju, Teng Wen, Hart Xiangping, Yin Qing, Xu Yuanli, Jin Fangyuan, Zhou Zaitong, Liu Hongxing.(2015).Mutaome analysis including 10 common mutated genes in newly diagnosed acute myeloid leukemia patients . Journal of Leukemia & Lymphoma,24(3):161-4.

10. Familial hemophagocytic lymphohistiocytosis associated gene mutations in Chinese lymphoma patients with human herpes virus infection

Chen Xue, Zhang Yang, Wang Fang, Teng Wen, Wang Mangju, Jin Fangyuan, Guo Lei, Wang Mingyu, Tong Chunrong, Liu Hongxing. (2015).Familial hemophagocytic lymphohistiocytosis associated gene mutations in Chinese lymphoma patients with human herpes virus infection . Journal of Leukemia &Lymphoma,24(2):91-5.

11. Maternal onset de novo SH2D1A mutation and lymphocytic choriomeningitis virus infection in a patient with Xlinked lymphoproliferative disease type 1: A case report

Liu J, Tian W, Wang F, et al.(2015). Maternal onset de novo SH2D1A mutation and lymphocytic choriomeningitis virus infection in a patient with Xlinked lymphoproliferative disease type 1: A case report. Mol Med Rep,11(5):3291-4. PMID: 25572984 

12. The BIM deletion polymorphism cannot account for intrinsic TKI resistance of Chinese individuals with CML

Xue Chen , Hongxing Liu , Haizhou Xing, et al.( 2014). The BIM deletion polymorphism cannot account for intrinsic TKI resistance of Chinese individuals with CML. Nature Medicine,20(10):1090. PMID: 25295932

13. Detection of JAK2 V617F gene mutation by loop mediated isothermal amplification (LAMP) technique

Zhang Yang, Chen Xue, Tian Wenjun,et al.(2014).Detection of JAK2 V617F gene mutation by loop mediated isothermal amplification (LAMP) technique .Chinese Journal of laboratory medicine,37(10):790-2.

14. Using recipient free edge fingernails for chimerism analysis following allogeneic hematopoietic stem-celltransplants

LIU Hong-xing , WANG Fang, TIAN Wen-jun, YU Xin-jian, ZHU Juan, HAN Xu, TENG Wen, XU Guo-lin, WANG Yan, GU Jiang-ying, ZHAO Yan-li, SUN Yuan, SUN Rui-juan, XU Fang, TONG Chun-rong , ZHU Ping. (2012).Using recipient free edge fingernails for chimerism analysis following allogeneic hematopoietic stem-celltransplants . Chinese Journal of Laboratory Medicine,35(1):23-6.

15. Mutation characteristics of ABL1 gene in 210 cases of imatinib resistant chronic myeloid leukemia and Ph positive acute lymphoblastic leukemia in China

Xia Junyan, Liu Hongxing, Wang Fang,et al.(2012). Mutation characteristics of ABL1 gene in 210 cases of imatinib resistant chronic myeloid leukemia and Ph positive acute lymphoblastic leukemia in China . J ournal of Experimental Hematology,35(1):17-22.

16. An analysis of etiological and genetic factors of a patient with familial hemophagocyticlymphohistiocytosis

LIU Hong-xing, TONG Chun-roug, WANG Hui, ZHU Juan, WANG Fang, CA1 Peng, TENG Wen, YANG Jun-fang, ZHANG Ya-li, LU Dao-pei.(2011).An analysis of etiological and genetic factors of a patient with familial hemophagocyticlymphohistiocytosis.Chinese Journal of Internal Medicine,50(2):132-5. PMID: 21418834

17. Detection of 5 kinds Of JAK2 gene mutations in myeloproliferative diseases by multiple site specific PCR

Liu Hongxing, Tong Chun Rong, Cai Peng, et al.(2009).Detection of 5 kinds Of JAK2 gene mutations in myeloproliferative diseases by multiple site specific PCR . Chinese Journal of Laboratory Medicine,. 2009;32:30-4.

18. Imatinib for treatment acute mixed cell leukemia of variant BCR/ABL fusion gene positive

Liu Hongxing, Cao Xingyu, Tong Chunrong,et al.(2009). Imatinib for treatment acute mixed cell leukemia of variant BCR/ABL fusion gene positive. Chinese Journal of Medicine,89:220-3. PMID: 19552835

19. Correlation of JAK2V617F Mutation in Patients with polycythemia Vera Thrombocythemia Burden with Clinical Features and Essential

LIU Hong-Xing, TONG Chun-Rong, CAI Peng, TENG Wen, WANG He, ZHANG Ying , ZHU Ping.(2009). Correlation of JAK2V617F Mutation in Patients with polycythemia Vera Thrombocythemia Burden with Clinical Features and Essential. Journal of Experimental Hematology,17:742-5. PMID: 19549399

20. Observation of a higher JAK2 V617F homozygous mutated clone in polycythemia vera compared to essential thrombocythemia

Liu Hongxing, TONG C, CAI P.(2008). Observation of a higher JAK2 V617F homozygous mutated clone in polycythemia vera compared to essential thrombocythemia. Front. Med. China,2:309-13. 

21. A Higher JAK2 V617F Homozygous Mutated Clone is Observed in Polycythemia Vera than in Primary Thrombocytosis

Liu Hongxing, Tong Chunrong, Cai Peng, Gu Jiangying, Lin Yuehui, Zhang Ying, Teng Wen, Wang He, Zhu Ping.(2008). A Higher JAK2 V617F Homozygous Mutated Clone is Observed in Polycythemia Vera than in Primary Thrombocytosis. Journal of Capital University of Medical Sciences,29:113-7.

22. Real-time PCR array for simultaneous detection of 37 kinds of fusion genes in leukemia

Liu Hongxing , ZHU Ping, ZHANG Ying, WANG Hong-xi, DU Jin-wei, LIU Jing, GU Jianv-yin, OU Yuan.(2007). Real-time PCR array for simultaneous detection of 37 kinds of fusion genes in leukemia.National Medical Journal of China,87:526-32. PMID: 17459201

23. Advances in Research and Application of Liquid Biopsy in Lymphoma

ZHANG Yang, LIU HongXing.(2017) Advances in Research and Application of Liquid Biopsy in Lymphoma. Journal of Experimental Hematology,25(4):1259-63.

24.Precise understanding and exploration of genetic pathogenic factors: from Mendel's genetic disease to genetic susceptibility

Chen Xue;Liu Hongxing.(2017). Precise understanding and exploration of genetic pathogenic factors: from Mendel's genetic disease to genetic susceptibility. Chinese Journal of Clinicians(Electronic Edition),11(3) :516-8.

25.Advances in research and application of immune repertoire analysis in hematological malignancies

Liu Hongxing, Chen Xue, Wang Fang.(2017).Advances in research and application of immune repertoire analysis in hematological malignancies .Journal of Leukemia & Lymphoma,26(2):68-70.

26. Progress of telomere and telomerase in hematological diseases

Liu Hongxing, Zhang Yang, Chen Xue.(2017). Progress of telomere and telomerase in hematological diseases. Journal of Leukemia &Lymphoma, 25 (1):12-14.

27. Advances in targeted therapy and cocktail targeted therapy for chronic myeloid leukemia

Zhang Yang, Chen Xue, Liu Hongxing.(2016). Advances in targeted therapy and cocktail targeted therapy for chronic myeloid leukemia. Journal of Leukemia & Lymphoma,25(10):632-6.

28. Advances in research and application of hematogenomics related pharmacogenomics

Zhou Fengye;Zhang Yang;Liu Hongxing.(2016).Advances in research and application of hematogenomics related pharmacogenomics. Chinese Journal of Clinicians(Electronic Edition),10(14) :2145-9.

29. Advances in research on human herpesvirus 8 related diseases and pathogenesis

Zhang Yubian;Chen Xue;Liu Hongxing.(2016).Advances in research on human herpesvirus 8 related diseases and pathogenesis. Chinese Journal of Clinicians(Electronic Edition),10(14) :2180-3.

30. Advances in personalized medicine of hematologic neoplasms and related pharmacogenetics

Liu Hongxing, Zhou Fengye, Zhang Yang .(2016).Advances in personalized medicine of hematologic neoplasms and related pharmacogenetics . Journal of Leukemia & Lymphoma,25(7):385-8, 393.

31. Advances in pathogenesis, diagnosis and treatment of paroxysmal nocturnal hemoglobinuria

Chen Xue,Zhang Yang,Liu Hongxing.(2016). Advances in pathogenesis, diagnosis and treatment of paroxysmal nocturnal hemoglobinuria.Journal of Leukemia & Lymphoma,25(4):252-6.

32. Advances in research and application of copy number variants in pediatric acute lymphoblastic leukemia: reports from the S7th American Society of Hematology annual meeting

Chen Xue, Dou Dandan, Zhang Yang, Wang Tong, Liu Hongxing .(2016). Advances in research and application of copy number variants in pediatric acute lymphoblastic leukemia: reports from the S7th American Society of Hematology annual meeting. Journal of Leukemia & Lymphoma,25(3):139-43.

33.Advances and enlightenment of myeloproliferative neoplasms associated gene mutations in thrombophilia and general population

Chen Xue, Zhang Yang, Liu Hongxing.(2015). Advances and enlightenment of myeloproliferative neoplasms associated gene mutations in thrombophilia and general population. Journal of Leukemia & Lymphoma,24(7):412-4, 419.

34.Research and application progression of gene mutations in leukemia: reports from the 56th American Society of Hematology annual meeting

Wang Fang, Zhang Yang, Chen Xue, Liu Hongxing.(2015) Research and application progression of gene mutations in leukemia: reports from the 56th American Society of Hematology annual meeting. Journal of Leukemia & Lymphoma,24(3):157-60.

35. Inherited and congenital predisposition to hematologic malignancies: reports from the 56th American Society of Hematology annual meeting

Chen Xue, Liu Hongxing.(2015).Inherited and congenital predisposition to hematologic malignancies: reports from the 56th American Society of Hematology annual meeting. Journal of Leukemia & Lymphoma,24(2):65-70.

36. Progression of molecular genetics in Ph-like acute lymphoblastic leukemia: reports from the 56th American Society of Hematology annual meeting

Zhang Yang, Liu Hongxing.(2015).Progression of molecular genetics in Ph-like acute lymphoblastic leukemia: reports from the 56th American Society of Hematology annual meeting. Journal of Leukemia & Lymphoma,24(2):74-78.

37. Research progress of tumor mutation group and the bright prospect of targeting cocktail therapy

Liu Hongxing.(2013). Research progress of tumor mutation group and the bright prospect of targeting cocktail therapy.China Prescription Drug,11(4):34-7.

38. Drug resistance  research and  treatmen progress of BCR-ABL1 kinase inhibitors

Liu Hongxing, Zhu Ping.(2011). Drug resistance  research and  treatmen progress of BCR-ABL1 kinase inhibitors.hot issues at the 52th American Society of Hematology annual meeting. Journal of Leukemia & Lymphoma,20(5):257-8. 

39. BCR-ABL fusion gene comprehensive detection strategy and precautions in clinical application

Liu Hongxing, Zhu Ping.(2008). BCR-ABL fusion gene comprehensive detection strategy and precautions in clinical application.Chinese Journal of Clinicians(Electronic Edition) , 2(7):826-31.

participated in editing books:

Clinical hematology examination”, published by people's Health Press, pending publication

“Application of transcriptome in precision medicine”,  published by Shanghai Jiao Tong University press, pending publication

Patent for invention

Liu Hongxing, Zhu Ping, Wang Qian, et al. A gene detection kit for detecting cell chimerism or individual recognition. Patent No.: CN200910178185.4